Project Title:
Investigation of the Effect of the Multi-Target Tyrosine Kinase Inhibitor Sunitinib on Lipopolysaccharide-Induced Acute Inflammation and Hypotension in Rats

Project Coordinator:
Dr. Faculty Member Şefika Pınar ŞENOL
Vocational School of Health Services
Department of Pharmacy Services

Project Duration:
6 Months

Mortality rates in intensive care units remain high due to sepsis, septic shock, and multiple organ failure. In recent years, the number of preclinical and clinical studies focusing on treatment approaches targeting tyrosine kinase receptors (TKRs) for sepsis-induced cardiovascular and renal dysfunction has been steadily increasing.

In this project, which will be conducted for the first time in this field, it is aimed to investigate the effect of sunitinib on NO-mediated hypotension in a lipopolysaccharide (LPS)-induced septic shock model in rats, by associating this effect with inflammatory signaling pathways, related pro-inflammatory mediators, and oxidative stress.

The data obtained from this study are expected to contribute to the literature in terms of developing TKR inhibitors for the prevention and treatment of systemic inflammatory diseases such as septic shock, which are accompanied not only by hypotension caused by bacterial infections but also by vascular, cardiac, and renal dysfunction along with inflammation.